Northwest Florida Beaches International Airport (ECP) is located in Panama City, Florida. This is about a forty-five minute drive or Uber ride to the Seaside/Watercolor area.
Destin-Fort Walton Beach Airport (VPS) is about an hour drive or Uber ride to the Seaside/Watercolor area.
It is important to note that if you are staying in WaterColor or a town nearby (Seaside, Seagrove) a car is not necessary. Once you arrive to the town from the Airport (via Uber etc.), everything is within walking distance (or biking).